抗小鼠血小板减少(CD42b )抗体 Antibodies for Platelet Depletion in mouse

背景资料: This antibody preparation contains a mixture of purified rat monoclonal antibodiesdirected against mouse GPIb (CD42b). Targeting of this receptor with divalent IgGs results inprofound and i

  • 货号: R300 (emfret)

背景资料: 

This antibody preparation contains a mixture of purified rat monoclonal antibodies directed against mouse GPIb (CD42b). Targeting of this receptor with divalent IgGs results in profound and irreversible Fc-independent platelet depletion in mice1,2 . Platelet depletion is frequently used to study the general role of platelets in (patho-) physiology3 .

保存条件:

The antibodies were purified from hybridoma cell culture supernatant by Protein G-Sepharose chromatography. 

Stable for six months from date of shipment when stored at 4°C. 

KEEP STERILE, the preparation contains no preservative. Aliquots can be stored at -20°C for at least one year. Avoid repeated freezing and thawing.

应用:

This preparation is optimized to reduce the platelet count by >95% within 60 minutes after intravenous injection of 2 µg/g bodyweight. It is recommended to inject the antibodies in a volume of 100-200 µl (diluted with sterile PBS).

同型对照(抗体来源): Rat IgG (Wistar)

缓冲液: 0.5 mg purified immunoglobulins in PBS, 0.2% (w/v) BSA, sterile filtered

浓度: 0.5 mg/ml